Modern Quantum Mechanics Model
The genetic code of each and every individual organism can tell a lot about its ancestors, some basic characteristics and biases toward potential diseases. However, there are differences between individuals and species that are not recorded in the 4-letter genetic code but in its packaging and handling. Epigenetics is defined as any factor influencing gene expression. Epigenetic mechanisms are important for normal functionality while their malfunction may lead to several diseases including cancer. They also take place in heredity and might be used to endow acquired traits.
Epigenetic Mechanisms
The DNA an organism carries encodes for all the proteins needed in any tissue at any time (and some non protein coding genes). The expression of each gene should be tightly regulated in time and space in order for a specific cell and the entire organism to function. Mutations in the genes or the factors controlling their regulation might lead to malfunctioning. For an instance, Prader-Willi syndrome is caused by genetic and epigenetic errors to the same part of chromosome 15. Every internal factor determining the gene expression profile can be considered as an epigenetic mechanism, two of which, DNA methylation and histone modifications, are the major ones.
DNA methylation is a modification in which a small molecule is attached to the DNA bases, usually Cytosine ones. DNA methylation occurs in all vertebrates, as far as scientists know. The modification silences the expression of the genes near the modification site leading to differential gene expression.
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